Biological Age

Obesity accelerates epigenetic aging measurably, particularly in liver tissue. As a predictor of biological age, though, BMI is far weaker than a blood panel.

Around 10-20% of people with fatty liver have a normal BMI. Losing 7-10% of body weight resolves steatohepatitis in most who achieve it.

Meta-analysis of randomized trials puts the effect at about 1 mmHg systolic per kilogram lost, and the response begins within weeks.

Risk rises steeply with BMI, but waist predicts better — and a 7% weight loss with activity cut progression by 58% in the Diabetes Prevention Program.

Metabolically healthy obesity exists, but follow-up studies show most people transition out of it, and risk is still higher than for healthy-weight peers.

Across 239 studies and 10.6 million adults, all-cause mortality is lowest between BMI 20 and 25 and rises about 30% per 5 units above 25.

Normal BMI, high body fat, central storage. The pattern carries a cardiometabolic profile closer to obesity than to the healthy weight the index reports.

Zombie cells build up with age and sustain inflammation: what senolytics are, what is proven in mice and in humans, and why self-treating with them is a bad idea.

Inflammaging is the low-grade inflammation that builds with age and tracks with heart disease, diabetes and dementia: where it comes from and what lowers it.

The core blood tests for aging are blood pressure, glucose and HbA1c, a lipid panel and waist circumference — read as a trend, not as one isolated number.